August 12, 2019

Robert Coffin
Chief Executive Officer
Replimune Group, Inc.
18 Commerce Way
Woburn, MA 01801

       Re: Replimune Group, Inc.
           Registration Statement on Form S-3
           Filed August 8, 2019
           File No. 333-233147

Dear Dr. Coffin:

       This is to advise you that we have not reviewed and will not review your

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Sonia Bednarowski at 202-551-3666 with any questions.


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