Replimune Group, Inc.

18 Commerce Way

Woburn, MA  01801


July 17, 2018




United States Securities and Exchange Commission

Division of Corporation Finance

Office of Healthcare & Insurance

100 F Street, N.E.

Washington, D.C. 20549-6010



Dorrie Yale




Replimune Group, Inc. Registration Statement on Form S-1 (Registration No. 333-225846)


Dear Ms. Yale:


In accordance with Rule 461 of Regulation C of the General Rules and Regulations under the Securities Act of 1933, as amended, we hereby request acceleration of the effective date of the Registration Statement on Form S-1 (File No. 333-225846) (the “Registration Statement”) of Replimune Group, Inc. (the “Company”). We respectfully request that the Registration Statement become effective as of 3:30 p.m., Eastern time, on July 19, 2018, or as soon as practicable thereafter.  Once the Registration Statement has been declared effective, please orally confirm that event with our counsel, Morgan, Lewis & Bockius LLP, by calling Gitte J. Blanchet at (617) 951-8211.


[Remainder of page intentionally left blank]




Very truly yours,




Replimune Group, Inc.





/s/ Robert Coffin 



Robert Coffin



President and Chief Executive Officer




Philip Astley-Sparke, Replimune Group, Inc.


Timothy J. Corbett, Morgan, Lewis & Bockius LLP


Gitte J. Blanchet, Morgan, Lewis & Bockius LLP


William V. Fogg, Cravath, Swaine & Moore LLP


Johnny G. Skumpija, Cravath, Swaine & Moore LLP


[Signature Page to Request for Acceleration of Effectiveness of Registration Statement]